{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:41:16Z","timestamp":1781102476220,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,5,15]]},"abstract":"<jats:p>Marfan syndrome is a systemic disorder of the connective tissue inherited as an autosomal dominant trait. The disorder imparts significant morbidity and mortality. The etiology of the disorder remains elusive. A recent study localized the gene for Marfan syndrome on chromosome 15. We present data showing that marker D15S48 is genetically linked to Marfan syndrome. Pairwise linkage analysis gave a maximum lod (logarithm of odds) score of Z = 11.78 at theta = 0.02. Furthermore our data suggest that the Marfan syndrome locus is possibly flanked on either side by D15S48 and D15S49.<\/jats:p>","DOI":"10.1073\/pnas.88.10.4486","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:38:38Z","timestamp":1149061118000},"page":"4486-4488","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["Marfan syndrome is closely linked to a marker on chromosome 15q1.5----q2.1."],"prefix":"10.1073","volume":"88","author":[{"given":"P","family":"Tsipouras","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington 06030."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sarfarazi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington 06030."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington 06030."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Weiffenbach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington 06030."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Boxer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington 06030."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,5,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.10.4486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:19:47Z","timestamp":1649855987000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.10.4486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5,15]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,5,15]]}},"alternative-id":["10.1073\/pnas.88.10.4486"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.10.4486","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5,15]]},"assertion":[{"value":"1991-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}