{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:33:16Z","timestamp":1781105596133,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,11,15]]},"abstract":"<jats:p>The mechanisms regulating growth and differentiation of B-cell precursors in adult bone marrow (BM) and\/or selecting immunocompetent cells for peripheral export are poorly understood. We report here that small numbers of activated peritoneal B cells selectively suppress the numbers of small pre-B (B220+IgM-) and B (B220+IgM+) cells in BM, if transferred into syngeneic adult mice. No significant alterations are detected in other BM cell lineages or in peripheral lymphocytes of recipient mice. Both CD5+ and CD5- peritoneal B cells display this activity, but the same or higher numbers of similarly activated splenic B cells have no effect. Suppression of B-lineage cells is independent of T lymphocytes but requires that both donor and recipient are matched for immunoglobulin allotypes. These findings provide evidence for regulation of BM B-cell production by peripheral B cells, especially when located in the peritoneal cavity, and ascribe regulatory roles to the peritoneal B-cell compartment. They also could contribute to understanding the control of total B-lymphocyte numbers in the organism.<\/jats:p>","DOI":"10.1073\/pnas.88.22.9944","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:50:38Z","timestamp":1149061838000},"page":"9944-9948","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":7,"title":["Peritoneal B cells regulate the numbers of allotype-matched pre-B and B cells in bone marrow."],"prefix":"10.1073","volume":"88","author":[{"given":"M A","family":"Marcos","sequence":"first","affiliation":[{"name":"Unit\u00e9 d'Immunobiologie, Centre National de la Recherche Scientifique UA359, Institut Pasteur, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sundblad","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunobiologie, Centre National de la Recherche Scientifique UA359, Institut Pasteur, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Malench\u00e8re","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunobiologie, Centre National de la Recherche Scientifique UA359, Institut Pasteur, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunobiologie, Centre National de la Recherche Scientifique UA359, Institut Pasteur, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,11,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.22.9944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:19:14Z","timestamp":1649855954000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.22.9944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,15]]},"references-count":0,"journal-issue":{"issue":"22","published-print":{"date-parts":[[1991,11,15]]}},"alternative-id":["10.1073\/pnas.88.22.9944"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.22.9944","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11,15]]},"assertion":[{"value":"1991-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}