{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:21:04Z","timestamp":1790508064919,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"23","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:p>Superoxide dismutase (SOD) rapidly scavenges superoxide (O2-) and also prolongs the vasorelaxant effects of nitric oxide (NO), thought to be the endothelium-derived relaxing factor. This prolongation has been ascribed to prevention of the reaction between O2- with NO. We report that SOD supports a reversible reduction of NO to NO-. When cyanamide and catalase were used to generate NO- in the presence of SOD, NO was measured by the conversion of HbO2 to MetHb. When SOD[Cu(I)] was exposed to NO anaerobically, NO- was trapped by MetHb forming nitrosylmyoglobin. When NO was generated by 3-morpholinosydnonimine hydrochloride in the presence of SOD, NO- or a similar reductant was formed, which reduced catalase compound II and promoted the formation of the catalase [Fe(III)]-NO complex. It is, therefore, conceivable that SOD may protect NO and endothelium-derived relaxing factor by a mechanism in addition to O2- scavenging and that NO- may be a physiologically important form of endothelium-derived relaxing factor.<\/jats:p>","DOI":"10.1073\/pnas.88.23.10860","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:51:47Z","timestamp":1149061907000},"page":"10860-10864","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":231,"title":["Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase."],"prefix":"10.1073","volume":"88","author":[{"given":"M E","family":"Murphy","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Physiologische Chemie I, Universit\u00e4t D\u00fcsseldorf, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Sies","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologische Chemie I, Universit\u00e4t D\u00fcsseldorf, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,12]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.23.10860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:19:05Z","timestamp":1649855945000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.23.10860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":0,"journal-issue":{"issue":"23","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1073\/pnas.88.23.10860"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.23.10860","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]},"assertion":[{"value":"1991-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}