{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:51:19Z","timestamp":1781106679995,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,3,15]]},"abstract":"<jats:p>Mutations at three loci in the mouse--W, Steel Sl), and microphthalmia (mi)--can lead to a deficiency in melanocytes and mast cells. As well, W and Sl mutants can be anemic and sterile, whereas mi mice are osteopetrotic due to a monocyte\/macrophage defect. Recent data have shown that the c-kit receptor tyrosine kinase is the gene product of the W locus, whereas Sl encodes the ligand for this growth factor receptor. We show here that ectopic expression of c-fms, a gene that encodes a macrophage growth factor receptor that is closely related to the c-kit receptor, complements mutations at the W locus in an in vitro mast cell\/fibroblast coculture system but is unable to reverse the inability of mi\/mi mast cells to survive under these conditions. Furthermore, mast cells expressing the c-fms receptor survive on a monolayer of fibroblasts homozygous for the Sl mutation. These results suggest that ligand binding to the c-kit or c-fms receptor activates identical or overlapping signal transduction pathways. Furthermore, they suggest that mi encodes a protein necessary for transducing signals mediated by way of either the c-kit or c-fms receptor.<\/jats:p>","DOI":"10.1073\/pnas.88.6.2341","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:56:31Z","timestamp":1149062191000},"page":"2341-2345","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice."],"prefix":"10.1073","volume":"88","author":[{"given":"P","family":"Dubreuil","sequence":"first","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Forrester","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rottapel","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Reedijk","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fujita","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,3,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.6.2341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:13:56Z","timestamp":1649855636000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.6.2341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3,15]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,3,15]]}},"alternative-id":["10.1073\/pnas.88.6.2341"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.6.2341","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3,15]]},"assertion":[{"value":"1991-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}