{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:00:44Z","timestamp":1781110844990,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,3,15]]},"abstract":"<jats:p>This paper reports the cloning and sequencing of a quail homeobox-containing gene, Quox-1, and its expression pattern in embryos from 3 to 6 days (E3 to E6) of development as determined by in situ hybridization. The opening reading frame in cDNA clone g11 corresponds to a predicted protein of 242 amino acids. Quox-1 protein displays high sequence similarity to the Antennapedia family, especially to the mouse homeodomain-containing protein Hox-1.1 (100% identity in the homeobox region, 77% at the 5' end beyond the homeobox). However, the carboxyl-terminal domain of the postulated protein has no significant homology with other known homeoproteins, including Hox-1.1. In situ hybridization experiments showed that Quox-1 is widely expressed in the developing central nervous system including the entire brain and the spinal cord. Outside the central nervous system, transcription of Quox-1 was mainly detected in the endoderm-derived epithelium of esophagus, trachea, and other digestive organs, as well as in the sensory epithelium of the olfactory region and perichondrium of the vertebrae. Thus, Quox-1 transcripts have a remarkably wide distribution that, unlike the other vertebrate homeobox genes examined to date, encompasses the rostral part of the developing nervous system, including the forebrain.<\/jats:p>","DOI":"10.1073\/pnas.88.6.2427","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:56:31Z","timestamp":1149062191000},"page":"2427-2431","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Quox-1, a quail homeobox gene expressed in the embryonic central nervous system, including the forebrain."],"prefix":"10.1073","volume":"88","author":[{"given":"Z G","family":"Xue","sequence":"first","affiliation":[{"name":"Institut d'Embryologie Cellulaire et Mol\u00e9culaire du Centre National de la Recherche Scientifique et du Coll\u00e8ge de France, Nogent-sur-Marne."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W J","family":"Gehring","sequence":"additional","affiliation":[{"name":"Institut d'Embryologie Cellulaire et Mol\u00e9culaire du Centre National de la Recherche Scientifique et du Coll\u00e8ge de France, Nogent-sur-Marne."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N M","family":"Le Douarin","sequence":"additional","affiliation":[{"name":"Institut d'Embryologie Cellulaire et Mol\u00e9culaire du Centre National de la Recherche Scientifique et du Coll\u00e8ge de France, Nogent-sur-Marne."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,3,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.6.2427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:14:36Z","timestamp":1649855676000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.6.2427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3,15]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,3,15]]}},"alternative-id":["10.1073\/pnas.88.6.2427"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.6.2427","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3,15]]},"assertion":[{"value":"1991-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}