{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:32:38Z","timestamp":1791181958869,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p>During in vitro incubation, prolactin release is inhibited in a dose-related manner by cortisol. This action is mimicked by the synthetic glucocorticoid agonist dexamethasone but not by other steroids tested. Perifusion studies indicate that the inhibition of [3H]prolactin release by cortisol occurs within 20 min. Cortisol (50 nM) also inhibits cAMP accumulation and reduces 45Ca2+ accumulation in the tilapia rostral pars distalis within 15 min. Cortisol's action on prolactin release is blocked in the presence of either the Ca2+ ionophore A23187 or a combination of dibutyryl cAMP and 3-isobutyl-1-methylxanthine, which increase intracellular Ca2+ and cAMP, respectively. Taken together, these findings suggest that cortisol may play a physiologically relevant role in the rapid modulation of prolactin secretion in vivo. Our studies also suggest that the inhibition of prolactin release by cortisol is a specific glucocorticoid action that may be mediated, in part, through cortisol's ability to inhibit intracellular cAMP and Ca2+ metabolism.<\/jats:p>","DOI":"10.1073\/pnas.88.7.2758","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:56:40Z","timestamp":1149062200000},"page":"2758-2762","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":83,"title":["Cortisol rapidly reduces prolactin release and cAMP and 45Ca2+ accumulation in the cichlid fish pituitary in vitro."],"prefix":"10.1073","volume":"88","author":[{"given":"R J","family":"Borski","sequence":"first","affiliation":[{"name":"Department of Zoology and the Hawaii Institute of Marine Biology, University of Hawaii, Honolulu, HI 96822, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Helms","sequence":"additional","affiliation":[{"name":"Department of Zoology and the Hawaii Institute of Marine Biology, University of Hawaii, Honolulu, HI 96822, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"3rd","given":"N H","family":"Richman","sequence":"additional","affiliation":[{"name":"Department of Zoology and the Hawaii Institute of Marine Biology, University of Hawaii, Honolulu, HI 96822, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E G","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Zoology and the Hawaii Institute of Marine Biology, University of Hawaii, Honolulu, HI 96822, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,4]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.7.2758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:04:34Z","timestamp":1649855074000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.7.2758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["10.1073\/pnas.88.7.2758"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.7.2758","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4]]},"assertion":[{"value":"1991-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}