{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:39:39Z","timestamp":1789378779947,"version":"build-2803163510"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,4,15]]},"abstract":"<jats:p>Identification of genes determining narcolepsy susceptibility is important not only for understanding that disorder but also for possible clues to general sleep-control mechanisms. Studies in humans reveal at least one such gene related to the major histocompatibility complex and in dog an as-yet-unmapped single, autosomal recessive gene canarc-1. Gene markers for canarc-1 were therefore sought by DNA restriction fragment length polymorphisms in our colony of narcoleptic dogs. A human mu-switch immunoglobulin probe and the enzyme Hae III identified a gene cosegregating with canarc-1 in backcrossed animals (logarithm of odds scores: m = 24, Z max = 7.2 at theta = 0%). canarc-1 was also shown not to be tightly linked with the dog major histocompatibility complex (m = 40, Z less than -2 at theta less than 4.8%). These results represent the mapping of a non-major histocompatibility complex narcolepsy gene and strongly suggest involvement of the immune system in the pathophysiology of that disease.<\/jats:p>","DOI":"10.1073\/pnas.88.8.3475","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:57:47Z","timestamp":1149062267000},"page":"3475-3478","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment."],"prefix":"10.1073","volume":"88","author":[{"given":"E","family":"Mignot","sequence":"first","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wang","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Rattazzi","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gaiser","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lovett","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Guilleminault","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Dement","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F C","family":"Grumet","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,4,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.8.3475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:10:12Z","timestamp":1649855412000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.8.3475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4,15]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,4,15]]}},"alternative-id":["10.1073\/pnas.88.8.3475"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.8.3475","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4,15]]},"assertion":[{"value":"1991-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}