{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:15:38Z","timestamp":1781104538961,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1992,6,15]]},"abstract":"<jats:p>V(D)J [variable-(diversity)-joining] rearrangements occur between, as well as within, immune receptor loci, resulting in the generation of hybrid antigen-receptor genes and the formation of a variety of lymphocyte-specific chromosomal aberrations. Such hybrid genes occur at a low frequency in the peripheral blood lymphocytes (PBL) of normal individuals but show a markedly increased incidence in the PBL of individuals with the autosomal recessive disease ataxia-telangiectasia. In this manuscript we demonstrate that the frequency of hybrid antigen-receptor genes is 10- to 20-fold increased in the PBL of an occupational group, agriculture workers, with related environmental exposures. Both ataxia-telangiectasia patients and this population of agriculture workers are at increased risk for lymphoid malignancy. This result suggests that the measurement of hybrid antigen receptor-genes in PBL may be a sensitive assay for a type of lymphocyte-specific genomic instability. As a corollary, this assay may identify populations at risk of developing common types of lymphoid malignancy.<\/jats:p>","DOI":"10.1073\/pnas.89.12.5301","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:02:18Z","timestamp":1149062538000},"page":"5301-5305","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies."],"prefix":"10.1073","volume":"89","author":[{"given":"S","family":"Lipkowitz","sequence":"first","affiliation":[{"name":"National Cancer Institute-Navy Medical Oncology Branch, Bethesda Naval Hospital, MD 20889-5105."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V F","family":"Garry","sequence":"additional","affiliation":[{"name":"National Cancer Institute-Navy Medical Oncology Branch, Bethesda Naval Hospital, MD 20889-5105."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I R","family":"Kirsch","sequence":"additional","affiliation":[{"name":"National Cancer Institute-Navy Medical Oncology Branch, Bethesda Naval Hospital, MD 20889-5105."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1992,6,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.89.12.5301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:02:52Z","timestamp":1649854972000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.89.12.5301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6,15]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1992,6,15]]}},"alternative-id":["10.1073\/pnas.89.12.5301"],"URL":"https:\/\/doi.org\/10.1073\/pnas.89.12.5301","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6,15]]},"assertion":[{"value":"1992-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}