{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:02:12Z","timestamp":1790355732255,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:p>The presence of a human T-cell lymphotropic virus (HTLV)-related endogenous sequence, HRES-1, in the human genome has been documented. The HRES-1 genomic locus is transcriptionally active and contains open reading frames. Antibodies 232 and 233, specific for synthetic peptides pep14-24 and pep117-127, corresponding to two nonoverlapping HTLV-related regions in the longer open reading frame of HRES-1, recognize an identical 28-kDa protein in H9 human T cells. Thus, HRES-1 is a human endogenous retroviral sequence capable of protein expression. HRES-1\/p28 is localized to the cytoplasm and nuclear bodies. While HTLV-I-specific antibodies react with HRES-1 peptides, antibody 233 cross-reacts with HTLV-I gag p24 protein. Three consecutive highly charged amino acid residues, Arg-Arg-Glu, present in both HRES-1 pep117-127 and HTLV-I gag p24 are likely to be the core of cross-reactive epitopes. The prevalence of antibodies to HRES-1 peptides pep14-24 and pep117-127 was determined in 65 normal blood donors and 146 patients with immunological disorders. Sera of patients with multiple sclerosis (19 out of 65, 29%), progressive systemic sclerosis (4 out of 17, 23%), systemic lupus erythematosus (4 out of 19, 21%), and Sjogren syndrome (2 out of 19, 10%) contained significantly higher HRES-1 peptide binding activity than sera of normal donors. Sera of patients with AIDS showed no specific binding to HRES-1 peptides. Nine of 30 HRES-1-seropositive patients showed immunoreactivity to HTLV-I gag p24. The data indicate that HRES-1\/p28 may serve as an autoantigen eliciting autoantibodies cross-reactive with HTLV-I gag antigens.<\/jats:p>","DOI":"10.1073\/pnas.89.5.1939","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:17:58Z","timestamp":1149063478000},"page":"1939-1943","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["Human T-cell lymphotropic virus (HTLV)-related endogenous sequence, HRES-1, encodes a 28-kDa protein: a possible autoantigen for HTLV-I gag-reactive autoantibodies."],"prefix":"10.1073","volume":"89","author":[{"given":"K","family":"Banki","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Maceda","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hurley","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ablonczy","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H","family":"Mattson","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Szegedy","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1992,3]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.89.5.1939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:42:16Z","timestamp":1649857336000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.89.5.1939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1073\/pnas.89.5.1939"],"URL":"https:\/\/doi.org\/10.1073\/pnas.89.5.1939","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]},"assertion":[{"value":"1992-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}