{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:54:51Z","timestamp":1781106891689,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1992,4,15]]},"abstract":"<jats:p>The endogenous inhibitory role of the neuropeptide galanin in pain transmission and spinal cord excitability was demonstrated by the use of a high-affinity galanin receptor antagonist, M-35 [galanin-(1-13)-bradykinin-(2-9)-amide]. M-35, which displaced 125I-labeled galanin from membranes of rat dorsal spinal cord with an IC50 of 0.3 nM, dose-dependently antagonized the effect of intrathecal galanin on the flexor reflex. M-35 potentiated the facilitation of the flexor reflex by conditioning stimulation of cutaneous unmyelinated afferents in rats with intact nerves and the potentiating effect of M-35 on the conditioning-stimulation-induced reflex facilitation of the cutaneous unmyelinated afferents was strongly enhanced after axotomy. These results demonstrate that endogenous galanin plays a tonic inhibitory role in the mediation of spinal cord excitability, and it is particularly noteworthy that this function of galanin is remarkably enhanced after peripheral nerve section.<\/jats:p>","DOI":"10.1073\/pnas.89.8.3334","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:19:52Z","timestamp":1149063592000},"page":"3334-3337","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":143,"title":["Galanin-mediated control of pain: enhanced role after nerve injury."],"prefix":"10.1073","volume":"89","author":[{"given":"Z","family":"Wiesenfeld-Hallin","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X J","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Langel","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Bedecs","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"H\u00f6kfelt","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bartfai","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1992,4,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.89.8.3334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:43:01Z","timestamp":1649857381000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.89.8.3334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,15]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1992,4,15]]}},"alternative-id":["10.1073\/pnas.89.8.3334"],"URL":"https:\/\/doi.org\/10.1073\/pnas.89.8.3334","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,15]]},"assertion":[{"value":"1992-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}