{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:39:55Z","timestamp":1791221995292,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1993,5,15]]},"abstract":"<jats:p>Progressive multifocal leukoencephalopathy results from an opportunistic infection of myelin-producing oligodendrocytes by the glia-specific human papovavirus JC. In this report, evidence is presented that the glial transcription factor Tst-1, a member of the POU-domain family, stimulates transcription of both early and late viral genes. Stimulation was dependent on site-specific binding of Tst-1 to the JC viral regulatory region and on the presence of an intact amino-terminal transactivation domain within Tst-1. Because of its ability to increase the expression of viral large tumor antigen, Tst-1 stimulated viral DNA replication, without participating directly in the replication event. Our results suggest that Tst-1 is one of the determining factors in the glia specificity of JC virus.<\/jats:p>","DOI":"10.1073\/pnas.90.10.4743","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:23:57Z","timestamp":1149063837000},"page":"4743-4747","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":69,"title":["Regulation of JC virus by the POU-domain transcription factor Tst-1: implications for progressive multifocal leukoencephalopathy."],"prefix":"10.1073","volume":"90","author":[{"given":"M","family":"Wegner","sequence":"first","affiliation":[{"name":"Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Drolet","sequence":"additional","affiliation":[{"name":"Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1993,5,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.90.10.4743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:40:00Z","timestamp":1649857200000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.90.10.4743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5,15]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,5,15]]}},"alternative-id":["10.1073\/pnas.90.10.4743"],"URL":"https:\/\/doi.org\/10.1073\/pnas.90.10.4743","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5,15]]},"assertion":[{"value":"1993-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}