{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:10:02Z","timestamp":1781104202177,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1993,11,15]]},"abstract":"<jats:p>Polymerase chain reaction amplification of cDNA from pig gastric mucosa demonstrated the presence of zinc-finger proteins called GATA-GT1, GATA-GT2, and GATA-GT3, each having zinc-finger sequences similar to previously characterized GATA-binding proteins. Subsequently, full-length cDNAs of GATA-GT1 and GATA-GT2 were obtained from rat stomach. The zinc-finger domains of GATA-GT1 and -GT2 were 66-86% identical on the amino acid level with each other and with other GATA-binding proteins. Potential protein kinase phosphorylation sites were present in the zinc-finger region. In contrast, regions outside the zinc fingers shared significantly lower similarities. GATA-GT2 was found to bind to the upstream sequence of the H+\/K(+)-ATPase beta gene and to a sequence containing the GATA motif. GATA-GT1 and -GT2 were expressed predominantly in the gastric mucosa and at much lower levels in the intestine (GATA-GT2, also in testis), their tissue distributions being distinct from those of GATA-1, -2, or -3. These results clearly suggest that GATA-GT1 and GATA-GT2 are involved in gene regulation specifically in the gastric epithelium and represent two additional members of the GATA-binding protein family.<\/jats:p>","DOI":"10.1073\/pnas.90.22.10876","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T20:21:57Z","timestamp":1149193317000},"page":"10876-10880","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":77,"title":["Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes."],"prefix":"10.1073","volume":"90","author":[{"given":"S","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry, Osaka University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X H","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry, Osaka University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry, Osaka University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Futai","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry, Osaka University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1993,11,15]]},"updated-by":[{"DOI":"10.1073\/pnas.91.10.4609","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1994,5,10]],"date-time":"1994-05-10T00:00:00Z","timestamp":768528000000}}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.90.22.10876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:30:19Z","timestamp":1649856619000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.90.22.10876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11,15]]},"references-count":0,"journal-issue":{"issue":"22","published-print":{"date-parts":[[1993,11,15]]}},"alternative-id":["10.1073\/pnas.90.22.10876"],"URL":"https:\/\/doi.org\/10.1073\/pnas.90.22.10876","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11,15]]},"assertion":[{"value":"1993-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}