{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:01:54Z","timestamp":1781103714747,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1994,5,10]]},"abstract":"<jats:p>Male (NZW x BXSB)F1 (W\/BF1) mice develop systemic autoimmunity involving autoantibodies, thrombocytopenia, lupus nephritis, and coronary vascular disease (CVD) with myocardial infarction. To determine whether this murine lupus-associated CVD can be prevented by the reduction of dietary calories, male W\/BF1 mice were separated into five experimental groups and fed either ad libitum (designated group A, n = 50), fed 32% fewer calories of an otherwise comparable diet (designated group B6, n = 20), or initially fed ad libitum and then switched to reduced calorie intake (RCI) feeding at ages 14, 17, or 22 weeks (designated B14, n = 10; B17, n = 20; or B22, n = 20). Occlusive CVD was prevented by RCI. Life-span was significantly extended among the early onset RCI cohorts, B6 and B14 (P = 0.0001 and P = 0.005), compared to group A mice. Mean anti-cardiolipin autoantibody titers and mean levels of circulating immune complexes were also lowered in RCI mice when all RCI mice were compared to ad libitum fed group A mice. Histological grades of both coronary vascular and glomerular lesions were significantly less than those of group A mice (P &lt; 0.001). Immunoprecipitates indicative of immunoglobulin deposition within coronary or glomerular vascular walls were also substantially less than those of group A mice. These findings indicate a possible causal role for anti-cardiolipin autoantibody in development of autoimmune CVD in W\/BF1 mice and suggest that regulating dietary calories can influence the mechanism involved in pathogenesis of autoimmune-associated CVD development.<\/jats:p>","DOI":"10.1073\/pnas.91.10.4402","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:46:31Z","timestamp":1149065191000},"page":"4402-4406","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["Calorie restriction prevents the occlusive coronary vascular disease of autoimmune (NZW x BXSB)F1 mice."],"prefix":"10.1073","volume":"91","author":[{"given":"H","family":"Mizutani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R W","family":"Engelman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kinjoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, All Children's Hospital, St. Petersburg 33701."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1994,5,10]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.91.10.4402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:43:54Z","timestamp":1649857434000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.91.10.4402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,5,10]]}},"alternative-id":["10.1073\/pnas.91.10.4402"],"URL":"https:\/\/doi.org\/10.1073\/pnas.91.10.4402","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5,10]]},"assertion":[{"value":"1994-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}