{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:38:07Z","timestamp":1781102287278,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1994,1,18]]},"abstract":"<jats:p>A synthetic peptide corresponding to an immunodominant epitope of lymphocytic choriomeningitis virus glycoprotein (LCMV GP) was used to prime or to tolerize CD8+ T cells in vivo, dependent on mode of immunization. Peptide-specific tolerance was then examined in transgenic mice expressing LCMV GP in the beta islet cells of the pancreas; these mice develop CD8+ T-cell-mediated diabetes within 8-14 days after LCMV infection. Specific peptide-induced tolerance prevented autoimmune destruction of beta islet cells and diabetes in this transgenic mouse model.<\/jats:p>","DOI":"10.1073\/pnas.91.2.444","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:56:02Z","timestamp":1149065762000},"page":"444-448","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model."],"prefix":"10.1073","volume":"91","author":[{"given":"P","family":"Aichele","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kyburz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Odermatt","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hengartner","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Pircher","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1994,1,18]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.91.2.444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:58:49Z","timestamp":1649858329000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.91.2.444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,1,18]]}},"alternative-id":["10.1073\/pnas.91.2.444"],"URL":"https:\/\/doi.org\/10.1073\/pnas.91.2.444","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1,18]]},"assertion":[{"value":"1994-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}