{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:14:28Z","timestamp":1781108068549,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1994,1,18]]},"abstract":"<jats:p>Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB\/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months and C57BL\/6 males beginning at 19 months. As melatonin is produced in circadian fashion from the pineal, we grafted pineals from young 3- to 4-month-old donors into the thymus of 20-month-old syngeneic C57BL\/6 male recipients, and a 12% increase in survival was induced. Prolongation of survival was also seen on pineal transplant to the thymus in C57BL\/6, BALB\/cJ, and hybrid female mice at 16, 19, and 22 months. In all studies, the endogenous pineal of grafted mice was left in situ. Pineal grafted aged mice display a remarkable maintenance of thymic structure and cellularity. Preservation of T-cell-mediated function, despite age, as measured by response to oxazolone is seen. Other evidence suggests that melatonin and\/or pineal-related factors could produce their effects through an influence on thyroid function. These data indicate that pineal influences have a place in the physiologic regulation of aging.<\/jats:p>","DOI":"10.1073\/pnas.91.2.787","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:56:02Z","timestamp":1149065762000},"page":"787-791","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":215,"title":["Pineal control of aging: effect of melatonin and pineal grafting on aging mice."],"prefix":"10.1073","volume":"91","author":[{"given":"W","family":"Pierpaoli","sequence":"first","affiliation":[{"name":"Biancalana-Masera Foundation for the Aged (Convention I.N.R.C.A. and University of Ancona), Neuroimmunomodulation Laboratory, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Regelson","sequence":"additional","affiliation":[{"name":"Biancalana-Masera Foundation for the Aged (Convention I.N.R.C.A. and University of Ancona), Neuroimmunomodulation Laboratory, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1994,1,18]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.91.2.787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:00:07Z","timestamp":1649858407000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.91.2.787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,1,18]]}},"alternative-id":["10.1073\/pnas.91.2.787"],"URL":"https:\/\/doi.org\/10.1073\/pnas.91.2.787","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1,18]]},"assertion":[{"value":"1994-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}