{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:37:37Z","timestamp":1781109457680,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1994,10,25]]},"abstract":"<jats:p>Pancreatic polypeptide, peptide tyrosine-tyrosine (PYY), and neuropeptide tyrosine (NPY), three members of a family of structurally related peptides, are mainly expressed in the endocrine pancreas, in endocrine cells of the gut, and in the brain, respectively. In the present study, we have isolated a peptide of the pancreatic polypeptide family from the skin of the South American arboreal frog Phyllomedusa bicolor. The primary structure of the peptide was established as Tyr-Pro-Pro-Lys-Pro-Glu-Ser-Pro-Gly-Glu10-Asp-Ala-Ser-Pro-Glu-Glu- Met-Asn- Lys-Tyr20-Leu-Thr-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu30-Val-Thr- Arg-Gln-Arg-Tyr-NH2 . This unusual peptide, named skin peptide tyrosine-tyrosine (SPYY), exhibits 94% similarity with PYY from the frog Rana ridibunda. A synthetic replicate of SPYY inhibits melanotropin release from perifused frog neurointermediate lobes in very much the same way as NPY. These results demonstrate the occurrence of a PYY-like peptide in frog skin. Our data also suggest the existence of a pituitary-skin regulatory loop in amphibians.<\/jats:p>","DOI":"10.1073\/pnas.91.22.10295","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:58:56Z","timestamp":1149065936000},"page":"10295-10299","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity."],"prefix":"10.1073","volume":"91","author":[{"given":"A","family":"Mor","sequence":"first","affiliation":[{"name":"Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Universit\u00e9 de Paris 7, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chartrel","sequence":"additional","affiliation":[{"name":"Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Universit\u00e9 de Paris 7, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Vaudry","sequence":"additional","affiliation":[{"name":"Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Universit\u00e9 de Paris 7, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Universit\u00e9 de Paris 7, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1994,10,25]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.91.22.10295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:04:17Z","timestamp":1649858657000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.91.22.10295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,25]]},"references-count":0,"journal-issue":{"issue":"22","published-print":{"date-parts":[[1994,10,25]]}},"alternative-id":["10.1073\/pnas.91.22.10295"],"URL":"https:\/\/doi.org\/10.1073\/pnas.91.22.10295","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10,25]]},"assertion":[{"value":"1994-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}