{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:06:41Z","timestamp":1781104001253,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1994,2,15]]},"abstract":"<jats:p>Plasmacytomagenesis provides a murine model to\ndecipher progressive genetic events culminating in a B-cell neoplasia.\nActivation of the c-myc protooncogene by chromosomal translocation is considered\nan initiating event. Intracisternal A-type particles (IAPs) are defective\nretroviral-like structures present in the endoplasmic reticulum of plasmacytomas\n(PCTs). IAP proviral insertions have been documented to engender negative or\npositive effects on the expression of nearby cellular genes. We have isolated a\ngene, PANG (plasmacytoma-associated neuronal glycoprotein), that is ectopically\ntranscribed in a number of PCTs due to IAP long terminal repeat (LTR)\nactivation. A full-length PANG cDNA was isolated from an MPC-11 plasma cell\ntumor cDNA library and encodes a polypeptide of about 113 kDa with six\nimmunoglobulin C2-like and four type III fibronectin-like domains. PANG bears a\nstriking resemblance to axonal glycoproteins TAG-1 and F11 known to function in\nneuronal outgrowth. An extensive survey revealed a predominant 3.6-kb PANG\ntranscript in 60% (30 of 50) of PCTs as well as unique smaller and larger\nspecies. All other normal and transformed lymphoid and nonlymphoid cell lines\nand normal tissues were negative for PANG expression except for the brain,\nwherein unique 4.0- and 6.1-kb transcripts were detected. Reverse transcriptase\nPCR analysis revealed IAP LTR fusion to PANG mRNAs in five PCTs and in a\nneuroblastoma line. The 5' end of a mouse brain PANG cDNA was identical to\nthe MPC-11 PANG transcript except for the precise replacement of its 5' LTR\nsequence.<\/jats:p>","DOI":"10.1073\/pnas.91.4.1337","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:03:29Z","timestamp":1149066209000},"page":"1337-1341","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["PANG, a gene encoding a neuronal glycoprotein, isectopically activated by intracisternal A-type particle long terminal repeats inmurine plasmacytomas."],"prefix":"10.1073","volume":"91","author":[{"given":"M A","family":"Connelly","sequence":"first","affiliation":[{"name":"Department of Pathology, State University of New York,\rStony Brook 11794-5215."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C","family":"Grady","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of New York,\rStony Brook 11794-5215."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Mushinski","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of New York,\rStony Brook 11794-5215."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K B","family":"Marcu","sequence":"additional","affiliation":[{"name":"Department of Pathology, State University of New York,\rStony Brook 11794-5215."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1994,2,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.91.4.1337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:48:08Z","timestamp":1649857688000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.91.4.1337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2,15]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,2,15]]}},"alternative-id":["10.1073\/pnas.91.4.1337"],"URL":"https:\/\/doi.org\/10.1073\/pnas.91.4.1337","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2,15]]},"assertion":[{"value":"1994-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}