{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:56:21Z","timestamp":1781110581740,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1994,3,29]]},"abstract":"<jats:p>Disintegrins are short soluble integrin ligands that were initially identified in snake venom. A previously recognized cellular protein with a disintegrin domain was the guinea pig sperm protein PH-30, a protein implicated in sperm-egg membrane binding and fusion. Here we present peptide sequences that are characteristic for several cellular disintegrin-domain proteins. These peptide sequences were deduced from cDNA sequence tags that were generated by polymerase chain reaction from various mouse tissue and a mouse muscle cell line. Northern blot analysis with four sequence tags revealed distinct mRNA expression patterns. Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions.<\/jats:p>","DOI":"10.1073\/pnas.91.7.2748","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:06:33Z","timestamp":1149066393000},"page":"2748-2751","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["A family of cellular proteins related to snake venom disintegrins."],"prefix":"10.1073","volume":"91","author":[{"given":"G","family":"Weskamp","sequence":"first","affiliation":[{"name":"Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C P","family":"Blobel","sequence":"additional","affiliation":[{"name":"Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1994,3,29]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.91.7.2748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:50:44Z","timestamp":1649857844000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.91.7.2748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3,29]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,3,29]]}},"alternative-id":["10.1073\/pnas.91.7.2748"],"URL":"https:\/\/doi.org\/10.1073\/pnas.91.7.2748","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3,29]]},"assertion":[{"value":"1994-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}