{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:54:48Z","timestamp":1781110488751,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1995,5,23]]},"abstract":"<jats:p>Translocations involving chromosome band 11q23, found in 5-10% of human acute leukemias, disrupt the ALL-1 gene. This gene is fused by reciprocal translocation with a variety of other genes in acute lymphoblastic and myelogenous leukemias, and it undergoes self-fusion in acute myeloid leukemias with normal karyotype or trisomy 11. Here we report an alteration of the ALL-1 gene in a gastric carcinoma cell line (Mgc80-3). Characterization of this rearrangement revealed a three-way complex translocation, involving chromosomes 1 and 11, resulting in a partial duplication of the ALL-1 gene. Sequencing of reverse transcription-PCR products and Northern blot analysis showed that only the partially duplicated ALL-1 gene was transcribed, producing an mRNA with exon 8 fused to exon 2. This report of ALL-1 gene rearrangement in a solid tumor suggests that ALL-1 plays a role in the pathogenesis of some solid malignancies. The absence of the normal transcript in this cell line, in association with the loss-of-heterozygosity studies on chromosome 11q23 seen in solid tumors, suggests that ALL-1 is involved in tumorigenesis by a loss-of-function mechanism.<\/jats:p>","DOI":"10.1073\/pnas.92.11.4922","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:11:38Z","timestamp":1149066698000},"page":"4922-4926","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["Involvement of the ALL-1 gene in a solid tumor."],"prefix":"10.1073","volume":"92","author":[{"given":"R","family":"Baffa","sequence":"first","affiliation":[{"name":"Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Negrini","sequence":"additional","affiliation":[{"name":"Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Schichman","sequence":"additional","affiliation":[{"name":"Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Huebner","sequence":"additional","affiliation":[{"name":"Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Croce","sequence":"additional","affiliation":[{"name":"Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1995,5,23]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.92.11.4922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:59:45Z","timestamp":1649858385000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.92.11.4922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,23]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1995,5,23]]}},"alternative-id":["10.1073\/pnas.92.11.4922"],"URL":"https:\/\/doi.org\/10.1073\/pnas.92.11.4922","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,23]]},"assertion":[{"value":"1995-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}