{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:15:06Z","timestamp":1781108106724,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1995,5,23]]},"abstract":"<jats:p>A human gene with strong homology to the MAGE gene family located in Xq27-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval. MAGE-Xp is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested. However, the gene and predicted protein structure are conserved, suggesting a similar function. MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita.<\/jats:p>","DOI":"10.1073\/pnas.92.11.4987","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:11:38Z","timestamp":1149066698000},"page":"4987-4991","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":72,"title":["Isolation and characterization of a MAGE gene family in the Xp21.3 region."],"prefix":"10.1073","volume":"92","author":[{"given":"F","family":"Muscatelli","sequence":"first","affiliation":[{"name":"Imperial Cancer Research Fund Laboratories, John Radcliffe Hospital, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P","family":"Walker","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund Laboratories, John Radcliffe Hospital, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"De Plaen","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund Laboratories, John Radcliffe Hospital, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A N","family":"Stafford","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund Laboratories, John Radcliffe Hospital, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P","family":"Monaco","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund Laboratories, John Radcliffe Hospital, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1995,5,23]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.92.11.4987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:00:20Z","timestamp":1649858420000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.92.11.4987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,23]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1995,5,23]]}},"alternative-id":["10.1073\/pnas.92.11.4987"],"URL":"https:\/\/doi.org\/10.1073\/pnas.92.11.4987","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,23]]},"assertion":[{"value":"1995-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}