{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:38:42Z","timestamp":1791189522491,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1995,6,6]]},"abstract":"<jats:p>The beta-amyloid precursor protein (beta-APP), from which the beta-A4 peptide is derived, is considered to be central to the pathogenesis of Alzheimer disease (AD). Transgenic mice expressing the 751-amino acid isoform of human beta-APP (beta-APP751) have been shown to develop early AD-like histopathology with diffuse deposits of beta-A4 and aberrant tau protein expression in the brain, particularly in the hippocampus, cortex, and amygdala. We now report that beta-APP751 transgenic mice exhibit age-dependent deficits in spatial learning in a water-maze task and in spontaneous alternation in a Y maze. These deficits were mild or absent in 6-month-old transgenic mice but were severe in 12-month-old transgenic mice compared to age-matched wild-type control mice. No other behavioral abnormalities were observed. These mice therefore model the progressive learning and memory impairment that is a cardinal feature of AD. These results provide evidence for a relationship between abnormal expression of beta-APP and cognitive impairments.<\/jats:p>","DOI":"10.1073\/pnas.92.12.5341","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:12:44Z","timestamp":1149066764000},"page":"5341-5345","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":293,"title":["Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein."],"prefix":"10.1073","volume":"92","author":[{"given":"P M","family":"Moran","sequence":"first","affiliation":[{"name":"Marion Merrell Dow Research Institute, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L S","family":"Higgins","sequence":"additional","affiliation":[{"name":"Marion Merrell Dow Research Institute, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Cordell","sequence":"additional","affiliation":[{"name":"Marion Merrell Dow Research Institute, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Moser","sequence":"additional","affiliation":[{"name":"Marion Merrell Dow Research Institute, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1995,6,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.92.12.5341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:12:15Z","timestamp":1649859135000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.92.12.5341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,6]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,6,6]]}},"alternative-id":["10.1073\/pnas.92.12.5341"],"URL":"https:\/\/doi.org\/10.1073\/pnas.92.12.5341","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6,6]]},"assertion":[{"value":"1995-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}