{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:07:22Z","timestamp":1791119242240,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:p>The CD3 epsilon polypeptide contributes to the cell surface display as well as to the signal transduction properties of the T-cell antigen receptor complex. Intriguingly, the distribution of CD3 epsilon is not restricted to T cells, since activated mouse, human, and avian natural killer (NK) cells do express intracytoplasmic CD3 epsilon polypeptides. CD3 epsilon is also present in the cytoplasm of fetal thymic T\/NK bipotential progenitor cells, suggesting that it constitutes a component of the NK differentiation program. We report here that the genetic disruption of CD3 epsilon exon 5 alters neither NK cell development nor in vitro and in vivo NK functions, although it profoundly blocked T-cell development. These results support the notion that CD3 epsilon is dispensable for mouse NK cell ontogeny and function and further suggest that the common NK\/T-cell progenitor cell utilizes CD3 epsilon as a mandatory component only when differentiating toward the T-cell lineage.<\/jats:p>","DOI":"10.1073\/pnas.92.16.7545","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:17:14Z","timestamp":1149067034000},"page":"7545-7549","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":28,"title":["Normal development and function of natural killer cells in CD3 epsilon delta 5\/delta 5 mutant mice."],"prefix":"10.1073","volume":"92","author":[{"given":"V","family":"Renard","sequence":"first","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ardouin","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Malissen","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Milon","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lebastard","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gillet","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Malissen","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Vivier","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale-Centre National de la Recherche Scientifique de Marseille-Luminy, Facult\u00e9 de Luminy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1995,8]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.92.16.7545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:08:05Z","timestamp":1649858885000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.92.16.7545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["10.1073\/pnas.92.16.7545"],"URL":"https:\/\/doi.org\/10.1073\/pnas.92.16.7545","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8]]},"assertion":[{"value":"1995-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}