{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:43:57Z","timestamp":1792885437377,"version":"4.5.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1995,2,28]]},"abstract":"<jats:p>Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.<\/jats:p>","DOI":"10.1073\/pnas.92.5.1664","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:27:59Z","timestamp":1149067679000},"page":"1664-1668","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1050,"title":["A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens."],"prefix":"10.1073","volume":"92","author":[{"given":"T K","family":"McDaniel","sequence":"first","affiliation":[{"name":"Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K G","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Donnenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Kaper","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1995,2,28]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.92.5.1664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:52:25Z","timestamp":1649857945000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.92.5.1664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2,28]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,2,28]]}},"alternative-id":["10.1073\/pnas.92.5.1664"],"URL":"https:\/\/doi.org\/10.1073\/pnas.92.5.1664","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2,28]]},"assertion":[{"value":"1995-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}