{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:59:20Z","timestamp":1791255560504,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1996,7,9]]},"abstract":"<jats:p>The interleukin 7 receptor (IL-7R) plays a crucial role in early B- and T-cell development. It consists of a unique a chain and a common gamma chain [IL-2 receptor gamma chain (IL-2Rgamma)]. Gene inactivation of IL-7, IL-7R, and IL-2Rgamma resulted in severe impairment of B and T lymphopoiesis in mice. In addition, IL-2Rgamma-deficient mice lack gammadelta T cells in the skin and have the impaired development of natural killer (NK) cells and intraepithelial lymphocytes. To explore the role of IL-7\/IL-7R system in gammadelta T- and NK-cell development, we have generated and analyzed IL-7R-deficient mice. gammadelta T cells were absent from skin, gut, liver, and spleen in the deficient mice. In contrast, alphabeta T and B cells were detected in reduced, but certain, numbers, and NK cells developed normally. The gammadelta T-cell development in fetal and adult thymus was also completely blocked. These results clearly demonstrate that the signal from IL-7R is indispensable for gammadelta T-cell development in both thymic and extrathymic pathways. On the contrary, it is suggested that NK-cell development requires cytokine(s) other than IL-7.<\/jats:p>","DOI":"10.1073\/pnas.93.14.7172","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:39Z","timestamp":1027679499000},"page":"7172-7177","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":253,"title":["Interleukin 7 receptor-deficient mice lack gammadelta T cells."],"prefix":"10.1073","volume":"93","author":[{"given":"K","family":"Maki","sequence":"first","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sunaga","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Komagata","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kodaira","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Karasuyama","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Yokomuro","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of Medicine, The Univerisity of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1996,7,9]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.93.14.7172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:37:59Z","timestamp":1649860679000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.93.14.7172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7,9]]},"references-count":0,"journal-issue":{"issue":"14","published-print":{"date-parts":[[1996,7,9]]}},"alternative-id":["10.1073\/pnas.93.14.7172"],"URL":"https:\/\/doi.org\/10.1073\/pnas.93.14.7172","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7,9]]},"assertion":[{"value":"1996-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}