{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:21:32Z","timestamp":1791019292652,"version":"4.1.0"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1996,12,10]]},"abstract":"<jats:p>\n                    Ocular cicatricial pemphigoid (OCP) is an autoimmune disease that\n affects mainly conjunctiva and other squamous epithelia. OCP is\n histologically characterized by a separation of the epithelium from\n underlying tissues within the basement membrane zone.\n Immunopathological studies demonstrate the deposition of anti-basement\n membrane zone autoantibodies\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Purified IgG from\n sera of patients with active OCP identified a cDNA clone from a human\n keratinocyte cDNA library that had complete homology with the\n cytoplasmic domain of \u03b24-integrin. The sera recognized a 205-kDa\n protein in human epidermal, human conjunctiva, and tumor cell lysates\n that was identified as \u03b24-integrin by its reaction with polyclonal\n and monoclonal antibodies to human \u03b24-integrin. Sera from patients\n with bullous pemphigoid, pemphigus vulgaris, and cicatricial\n pemphigoid-like diseases did not recognize the 205-kDa protein,\n indicating the specificity of the binding. These data strongly\n implicate a role for human \u03b24-integrin in the pathogenesis of OCP. It\n should be emphasized that multiple antigens in the basement membrane\n zone of squamous epithelia may serve as targets for a wide spectrum of\n autoantibodies observed in vesiculobullous diseases. Molecular\n definition of these autoantigens will facilitate the classification and\n characterization of subsets of cicatricial pemphigoid and help\n distinguishing them from bullous pemphigoid. This study highlights the\n function and importance of \u03b24-integrin in maintaining the attachment\n of epithelial cells to the basement membrane.\n                  <\/jats:p>","DOI":"10.1073\/pnas.93.25.14714","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:43:20Z","timestamp":1027680200000},"page":"14714-14719","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":123,"title":["Ocular cicatricial pemphigoid antigen: Partial sequence and\u2009biochemical\u2009characterization"],"prefix":"10.1073","volume":"93","author":[{"given":"Shivraj","family":"Tyagi","sequence":"first","affiliation":[{"name":"The Center for Blood Research, 200 Longwood Avenue, Harvard\r Medical School, Boston, MA 02115; and The Massachusetts Eye\r and Ear Infirmary and Department of Ophthalmology, Harvard Medical\r School, Boston, MA 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