{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:57:56Z","timestamp":1781110676638,"version":"3.54.1"},"reference-count":69,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1996,12,24]]},"abstract":"<jats:p>\n                    Nitric oxide (NO\n                    <jats:sup>\u00b7<\/jats:sup>\n                    ) does not react significantly\n with thiol groups under physiological conditions, whereas a variety of\n endogenous NO donor molecules facilitate rapid transfer to\n thiol of nitrosonium ion (NO\n                    <jats:sup>+<\/jats:sup>\n                    , with one less electron than\n NO\n                    <jats:sup>\u00b7<\/jats:sup>\n                    ). Here, nitrosonium donors are shown to decrease\n the efficacy of evoked neurotransmission while increasing the frequency\n of spontaneous miniature excitatory postsynaptic currents (mEPSCs). In\n contrast, pure NO\n                    <jats:sup>\u00b7<\/jats:sup>\n                    donors have little effect (displaying\n at most only a slight increase) on the amplitude of evoked EPSCs and\n frequency of spontaneous mEPSCs in our preparations. These findings may\n help explain heretofore paradoxical observations that the NO moiety can\n either increase, decrease, or have no net effect on synaptic activity\n in various preparations.\n                  <\/jats:p>","DOI":"10.1073\/pnas.93.26.15423","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:43:20Z","timestamp":1027680200000},"page":"15423-15428","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":39,"title":["Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal\u2009cultures"],"prefix":"10.1073","volume":"93","author":[{"given":"Zhuo-Hua","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital, and Program in\r Neuroscience, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u2009M.","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital, and Program in\r Neuroscience, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart\u2009A.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital, and Program in\r Neuroscience, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1996,12,24]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90505-K"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1720572"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11285"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90288-O"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.2.639"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00891.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00543.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90039-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199410270-00054"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/374262a0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/364626a0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90021-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.214.4519.435"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00340a038"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1281928"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/367028c0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90269-0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/380221a0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90130-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00115a013"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.9813"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.65.4.761"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7834"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90273-T"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90151-1"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90087-T"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91690-G"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.92.2.145"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.4.1874"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/336385a0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/376074a0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8721"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","unstructured":"Bates J.\u2009N. Baker M.\u2009T. Guerra Jr. R. & Harrison D.\u2009G. (1991) Biochem. Pharmacol. 42 Suppl. S157\u2013S165.","DOI":"10.1016\/0006-2952(91)90406-U"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","unstructured":"Noack E. & Feelisch M. (1991) Basic Res. Cardiol. 86 Suppl. 2 37\u201350.","DOI":"10.1007\/978-3-642-72461-9_5"},{"key":"e_1_3_2_35_2","volume-title":"Methods in Nitric Oxide Research","author":"Feelisch M","year":"1996","unstructured":", eds M Feelisch, J S Stamler (Wiley, Chichester, U.K. Methods in Nitric Oxide Research, 1996)."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-02668.1995"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/353558a0"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199205000-00008"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90223-Q"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90492-P"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7508638"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8100368"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.23.11292"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1519065"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90440-5"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7909958"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/375400a0"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90046-2"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/357134a0"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/346724a0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80027-6"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(90)90048-J"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/349326a0"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020189"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015893"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05312.1996"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/378196a0"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90733-7"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90342-5"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90352-Q"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90156-6"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90556-8"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90415-4"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90328-3"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/378733a0"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93898-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/366562a0"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(94)90203-8"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80149-X"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.93.26.15423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:35:18Z","timestamp":1649860518000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.93.26.15423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12,24]]},"references-count":69,"journal-issue":{"issue":"26","published-print":{"date-parts":[[1996,12,24]]}},"alternative-id":["10.1073\/pnas.93.26.15423"],"URL":"https:\/\/doi.org\/10.1073\/pnas.93.26.15423","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12,24]]},"assertion":[{"value":"1996-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}