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Long-term expression of apoptin in normal human fibroblasts revealed that apoptin has no toxic or transforming activity in these cells. In normal cells, apoptin was found predominantly in the cytoplasm, whereas in transformed and malignant cells it was located in the nucleus, suggesting that the localization of apoptin is related to its activity. These properties make apoptin a potential agent for the treatment of a large number of tumors, also those lacking p53 and\/or overexpressing Bcl-2.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.11.5843","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:39Z","timestamp":1027679499000},"page":"5843-5847","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":189,"title":["Apoptin induces apoptosis in human transformed and malignant cells but not in normal\u2009cells"],"prefix":"10.1073","volume":"94","author":[{"given":"A. A. A. M. 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