{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:44:10Z","timestamp":1781109850747,"version":"3.54.1"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,6,24]]},"abstract":"<jats:p>\n                    Cells from patients with xeroderma pigmentosum complementation group D (XP-D) and most patients with trichothiodystrophy (TTD) are deficient in excision repair of ultraviolet (UV) radiation-induced DNA damage. Although in both syndromes this defect is based on mutations in the same gene,\n                    <jats:italic>XPD<\/jats:italic>\n                    , only XP-D, not TTD, individuals have an increased risk of skin cancer. Since the reduction in DNA repair capacity is similar in XP-D and TTD patients, it cannot account for the difference in skin cancer risk. The features of XP-D and TTD might therefore be attributable to differences in the immune response following UV-irradiation, a factor which is presumed to be important for photocarcinogenesis. We have measured the capacity of UVB radiation to inhibit expression of the immunological key molecule intercellular adhesion molecule 1 (ICAM-1) in cells from three healthy individuals in comparison to cells from three XP-D and three TTD patients. Cells from XP-D patients, but not from TTD patients, exhibited an increased susceptibility to UVB radiation-induced inhibition of ICAM-1 expression. Transfection of XP-D cells with the wild-type\n                    <jats:italic>XPD<\/jats:italic>\n                    cDNA, but not with\n                    <jats:italic>XPC<\/jats:italic>\n                    cDNA, corrected this abnormal phenotype. Thus, the skin cancer risk in DNA repair-defective individuals correlated with the susceptibility of their cells to UVB radiation-induced inhibition of ICAM-1 expression, rather than with their defect in DNA repair. The XPD protein has dual roles: in DNA repair and transcription. The transcriptional role might be important for the control of expression of immunologically relevant genes and thereby contribute to the skin cancer risk of a DNA-repair-deficient individual.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.13.6837","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:39Z","timestamp":1027679499000},"page":"6837-6841","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective\u2009individuals"],"prefix":"10.1073","volume":"94","author":[{"given":"Constanze","family":"Ahrens","sequence":"first","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Grewe","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Berneburg","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Grether-Beck","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Quilliet","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Mezzina","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sarasin","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany; Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer, Unit\u00e9 Propre de Recherche 42 Centre National de la Recherche Scientifique, Boite Postala 8, F-94801 Villejuif, France; and Medical Research Council Cell Mutation Unit, University of Sussex, Falmer Brighton, BN1 9RR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Clinical and Experimental 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