{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:12:05Z","timestamp":1791198725429,"version":"4.1.0"},"reference-count":50,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,6,24]]},"abstract":"<jats:p>\n                    cAMP\/cAMP-dependent protein kinase (PKA) signaling pathway has been recently proposed to participate in both the late phase of long term potentiation in the hippocampus and in the late, protein synthesis-dependent phase of memory formation. Here we report that a late memory consolidation phase of an inhibitory avoidance learning is regulated by an hippocampal cAMP signaling pathway that is activated, at least in part, by D\n                    <jats:sub>1<\/jats:sub>\n                    \/D\n                    <jats:sub>5<\/jats:sub>\n                    receptors. Bilateral infusion of SKF 38393 (7.5 \u03bcg\/side), a D\n                    <jats:sub>1<\/jats:sub>\n                    \/D\n                    <jats:sub>5<\/jats:sub>\n                    receptor agonist, into the CA\n                    <jats:sub>1<\/jats:sub>\n                    region of the dorsal hippocampus, enhanced retention of a step-down inhibitory avoidance when given 3 or 6 h, but not immediately (0 h) or 9 h, after training. In contrast, full retrograde amnesia was obtained when SCH 23390 (0.5 \u03bcg\/side), a D\n                    <jats:sub>1<\/jats:sub>\n                    \/D\n                    <jats:sub>5<\/jats:sub>\n                    receptor antagonist, was infused into the hippocampus 3 or 6 h after training. Intrahippocampal infusion of 8Br-cAMP (1.25 \u03bcg\/side), or forskolin (0.5 \u03bcg\/side), an activator of adenylyl cyclase, enhanced memory when given 3 or 6 h after training. KT5720 (0.5 \u03bcg\/side), a specific inhibitor of PKA, hindered memory consolidation when given immediately or 3 or 6 h posttraining. Rats submitted to the avoidance task showed learning-specific increases in hippocampal\n                    <jats:sup>3<\/jats:sup>\n                    H-SCH 23390 binding and in the endogenous levels of cAMP 3 and 6 h after training. In addition, PKA activity and P-CREB (phosphorylated form of cAMP responsive element binding protein) immunoreactivity increased in the hippocampus immediately and 3 and 6 h after training. Together, these findings suggest that the late phase of memory consolidation of an inhibitory avoidance is modulated cAMP\/PKA signaling pathways in the hippocampus.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.13.7041","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:50Z","timestamp":1027679750000},"page":"7041-7046","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":425,"title":["Involvement of hippocampal cAMP\/cAMP-dependent protein kinase signaling pathways in a late memory consolidation  phase of aversively motivated learning in\u2009rats"],"prefix":"10.1073","volume":"94","author":[{"given":"Ramon","family":"Bernabeu","sequence":"first","affiliation":[{"name":"Instituto de Biologia Celular, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; and Centro de Memoria, Departamento de Bioquimica, Instituto de Biociencias, Porto Alegre, 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