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In this study, we show that two major oxidative DNA lesions, 8-oxoguanine and thymine glycol, are excised from DNA\n                    <jats:italic>in vitro<\/jats:italic>\n                    by the same enzyme system responsible for removing pyrimidine dimers and other bulky DNA adducts. Our results suggest that XP neurological disease may be caused by defective repair of lesions that are produced in nerve cells by reactive oxygen species generated as by-products of an active oxidative metabolism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.17.9463","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:52Z","timestamp":1027680052000},"page":"9463-9468","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":291,"title":["<i>In vitro<\/i>\n                    repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma  pigmentosum\u2009patients"],"prefix":"10.1073","volume":"94","author":[{"given":"Joyce T.","family":"Reardon","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599; and Department of Chemistry, Wesleyan University, Middletown, CT 06459"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayoshi","family":"Bessho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599; and Department of Chemistry, Wesleyan University, Middletown, CT 06459"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang Chuan","family":"Kung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599; and Department of Chemistry, Wesleyan University, Middletown, CT 06459"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H.","family":"Bolton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599; and Department of Chemistry, Wesleyan University, Middletown, CT 06459"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Sancar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599; and Department of Chemistry, Wesleyan University, Middletown, CT 06459"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1997,8,19]]},"reference":[{"key":"e_1_3_2_1_2","first-page":"2949","volume-title":"The Metabolic Basis of Inherited Disease","author":"Cleaver J E","year":"1989","unstructured":"J E Cleaver, K H Kraemer The Metabolic Basis of Inherited Disease, eds C R Scriver, A L Beaudet, W S Sly, D Valle (McGraw\u2013Hill, New York) 2, 2949\u20132971 (1989)."},{"key":"e_1_3_2_2_2","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg E C","year":"1995","unstructured":"E C Friedberg, G C Walker, W Siede DNA Repair and Mutagenesis (Am. 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