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This effect can be further enhanced in HeLa cells by the concurrent expression of the cyclin-dependent kinase activator, cyclin H, and cdk7, and abolished by expression of the cdk inhibitor, p27\n                    <jats:sup>KIP1<\/jats:sup>\n                    , or by the expression of a dominant negative catalytically inactive cdk2 mutant. ER is phosphorylated between amino acids 82 and 121\n                    <jats:italic>in vitro<\/jats:italic>\n                    by the cyclin A\/cdk2 complex and incorporation of phosphate into ER is stimulated by ectopic expression of cyclin A\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Together, these results strongly suggest a direct role for the cyclin A\/cdk2 complex in phosphorylating ER and regulating its transcriptional activity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.19.10132","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"10132-10137","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":79,"title":["Regulation of estrogen receptor transcriptional enhancement  by the cyclin A\/Cdk2\u2009complex"],"prefix":"10.1073","volume":"94","author":[{"given":"Janet M.","family":"Trowbridge","sequence":"first","affiliation":[{"name":"Department of Microbiology and The Kaplan Cancer Center, New York University Medical Center, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez","family":"Rogatsky","sequence":"additional","affiliation":[{"name":"Department of Microbiology and The Kaplan 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