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Leptin, injected intraperitoneally (i.p.) at low doses (4\u2013120 \u03bcg\/kg), which did not influence feeding behavior for the first 3 hr postinjection, decreased food intake dose dependently by 47\u201383% during the first hour when coinjected with a subthreshold dose of CCK. Such an interaction was not observed between leptin and bombesin. The food-reducing effect of leptin injected with CCK was not associated with alterations in gastric emptying or locomotor behavior. Leptin\u2013CCK action was blocked by systemic capsaicin at a dose inducing functional ablation of sensory afferent fibers and by devazepide, a CCK-A receptor antagonist but not by the CCK-B receptor antagonist, L-365,260. The decrease in food intake which occurs 5 hr after i.p. injection of leptin alone was also blunted by devazepide. Coinjection of leptin and CCK enhanced the number of Fos-positive cells in the hypothalamic paraventricular nucleus by 60%, whereas leptin or CCK alone did not modify Fos expression. These results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.<\/jats:p>","DOI":"10.1073\/pnas.94.19.10455","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:50Z","timestamp":1027679750000},"page":"10455-10460","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":375,"title":["Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean\u2009mice"],"prefix":"10.1073","volume":"94","author":[{"given":"Mar\u00eda Dolores","family":"Barrachina","sequence":"first","affiliation":[{"name":"CURE: Digestive Diseases Research Center, West Los Angeles Veterans Affairs Medical Center, Department of Medicine, and Brain Research Institute, University of California, Los Angeles, CA 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