{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:23:41Z","timestamp":1781105021525,"version":"3.54.1"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,9,30]]},"abstract":"<jats:p>\n                    The ability to tolerate a low-O\n                    <jats:sub>2<\/jats:sub>\n                    environment varies widely among species in the animal kingdom. Some animals, such as\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    , can tolerate anoxia for prolonged periods without apparent tissue injury. To determine the genetic basis of the cellular responses to low O\n                    <jats:sub>2<\/jats:sub>\n                    , we performed a genetic screen in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    to identify loci that are responsible for anoxia resistance. Four X-linked, anoxia-sensitive mutants belonging to three complementation groups were isolated after screening more than 10,000 mutagenized flies. The identified recessive and dominant mutations showed marked delay in recovery from O\n                    <jats:sub>2<\/jats:sub>\n                    deprivation. In addition, electrophysiologic studies demonstrated that polysynaptic transmission in the central nervous system of the mutant flies was abnormally long during recovery from anoxia. These studies show that anoxic tolerance can be genetically dissected.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.20.10809","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"10809-10812","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["Genetic basis of tolerance to O\n                    <sub>2<\/sub>\n                    deprivation in\n                    <i>Drosophila\u2009melanogaster<\/i>"],"prefix":"10.1073","volume":"94","author":[{"given":"Gabriel G.","family":"Haddad","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Biology, and Genetics, and the Boyer Center for Molecular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 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