{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:51:45Z","timestamp":1789872705965,"version":"4.0.1"},"reference-count":20,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,10,14]]},"abstract":"<jats:p>\n                    Lutropin (LH) and other glycoproteins bearing oligosaccharides with the terminal sequence SO\n                    <jats:sub>4<\/jats:sub>\n                    -4-GalNAc\u03b21,4GlcNAc\u03b21,4Man- (S4GGnM) are rapidly removed from the circulation by an S4GGnM-specific receptor (S4GGnM-R) expressed at the surface of hepatic endothelial cells. The S4GGnM-R isolated from rat liver is closely related to the macrophage mannose-specific receptor (Man-R) isolated from rat lung both antigenically and structurally. The S4GGnM-R and Man-R isolated from these tissues nonetheless differ in their ability to bind ligands bearing terminal GalNAc-4-SO\n                    <jats:sub>4<\/jats:sub>\n                    or Man. In this paper, we have explored the structural relationship between the Man-R and the S4GGnM-R by examining the properties of the recombinant Man-R in the form of a transmembrane protein and a soluble chimeric fusion protein in which the transmembrane and cytosolic domains have been replaced by the Fc region of human IgG1. Like the S4GGnM-R isolated from liver, the chimeric fusion protein is able to bind ligands terminating with GalNAc-4-SO\n                    <jats:sub>4<\/jats:sub>\n                    and Man at independent sites. When expressed in CHO cells the recombinant Man-R is able to mediate the uptake of ligands bearing either terminal GalNAc-4-SO\n                    <jats:sub>4<\/jats:sub>\n                    or terminal Man. We propose that the Man-R be renamed the Man\/S4GGnM receptor on the basis of its multiple and independent specificities.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.21.11256","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:32:33Z","timestamp":1027679553000},"page":"11256-11261","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":64,"title":["The macrophage\/endothelial cell mannose receptor cDNA encodes a protein that binds oligosaccharides terminating with SO\n                    <sub>4<\/sub>\n                    -4-GalNAc\u03b21,4GlcNAc\u03b2 or Man at independent\u2009sites"],"prefix":"10.1073","volume":"94","author":[{"given":"Dorothy","family":"Fiete","sequence":"first","affiliation":[{"name":"Department of Pathology, Washington University Medical School, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Beranek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington University Medical School, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques U.","family":"Baenziger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington University Medical School, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1997,10,14]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90287-9"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.334"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.5.8612480"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.14629"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38325-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.9.2363.bloodjournal8092363"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/oso\/9780199633913.003.0005","volume-title":"Cellular Interactions in Development: A Practical Approach","author":"Simmons D L","year":"1993","unstructured":"D L Simmons Cellular Interactions in Development: A Practical ApproachD A Hartley, ed D A Hartley (Oxford Univ. Press, Oxford), pp. 93\u2013127 (1993)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1785"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.6.2216"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36587-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90371-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54164-8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.09.110193.001321"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42060-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37546-4"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/375151a0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.35.21323"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.48.28869"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)46005-X"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.9.5668"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.94.21.11256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T23:47:29Z","timestamp":1704325649000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.94.21.11256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10,14]]},"references-count":20,"journal-issue":{"issue":"21","published-print":{"date-parts":[[1997,10,14]]}},"alternative-id":["10.1073\/pnas.94.21.11256"],"URL":"https:\/\/doi.org\/10.1073\/pnas.94.21.11256","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10,14]]},"assertion":[{"value":"1997-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}