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In this study, we demonstrate that these E6 proteins can bind to the second PDZ domain of the human homologue of the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    discs large tumor suppressor protein (hDLG) through their C-terminal XS\/TXV\/L (where X represents any amino acid, S\/T serine or threonine, and V\/L valine or leucine) motif. This finding is similar to the interaction between the adenomatous polyposis coli gene product and hDLG. E6 mutants losing the ability to bind to hDLG are no longer able to induce E6-dependent transformation of rodent cells. These results suggest an intriguing possibility that interaction between the E6 protein and hDLG or other PDZ domain-containing proteins could be an underlying mechanism in the development of HPV-associated cancers.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.21.11612","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"11612-11616","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":428,"title":["Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the\n                    <i>Drosophila<\/i>\n                    discs large tumor suppressor\u2009protein"],"prefix":"10.1073","volume":"94","author":[{"given":"Tohru","family":"Kiyono","sequence":"first","affiliation":[{"name":"Laboratory of Viral Oncology, Aichi Cancer Center, Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan; Department of Dermatology, Nagoya University, School of Medicine, Nagoya 466, Japan; and Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuro","family":"Hiraiwa","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Oncology, Aichi Cancer Center, Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan; Department of Dermatology, Nagoya University, School of Medicine, Nagoya 466, Japan; and Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Oncology, Aichi Cancer Center, Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan; Department of Dermatology, Nagoya University, School of Medicine, Nagoya 466, Japan; and Department of 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