{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:55:38Z","timestamp":1781110538160,"version":"3.54.1"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,10,14]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>Drosophila retinal degeneration C<\/jats:italic>\n                    (\n                    <jats:italic>rdgC<\/jats:italic>\n                    ) gene encodes an unusual protein\n serine\/threonine phosphatase in that it contains at least two EF-hand\n motifs at its carboxy terminus. By a combination of large-scale\n sequencing of human retina cDNA clones and searches of expressed\n sequence tag and genomic DNA databases, we have identified two\n sequences in mammals [\n                    <jats:italic>Protein Phosphatase with\n EF-hands-1<\/jats:italic>\n                    and\n                    <jats:italic>2<\/jats:italic>\n                    (\n                    <jats:italic>PPEF-1<\/jats:italic>\n                    and\n                    <jats:italic>PPEF-2<\/jats:italic>\n                    )] and one in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    (\n                    <jats:italic>PPEF<\/jats:italic>\n                    ) that closely resemble\n                    <jats:italic>rdgC<\/jats:italic>\n                    . In the\n adult,\n                    <jats:italic>PPEF-2<\/jats:italic>\n                    is expressed specifically in retinal rod\n photoreceptors and the pineal. In the retina, several isoforms of\n PPEF-2 are predicted to arise from differential splicing. The isoform\n that most closely resembles rdgC is localized to rod inner segments.\n Together with the recently described localization of\n                    <jats:italic>PPEF-1<\/jats:italic>\n                    transcripts to primary somatosensory neurons and\n inner ear cells in the developing mouse, these data suggest that the\n PPEF family of protein serine\/threonine phosphatases plays a specific\n and conserved role in diverse sensory neurons.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.21.11639","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:42:40Z","timestamp":1027680160000},"page":"11639-11644","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["Identification and characterization of a conserved family of protein serine\/threonine phosphatases homologous to\n                    <i>Drosophila<\/i>\n                    retinal degeneration C\u2009(rdgC)"],"prefix":"10.1073","volume":"94","author":[{"given":"Patti M.","family":"Sherman","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Department\r of Neuroscience,Department of Ophthalmology, and\r Howard Hughes Medical Institute, The Johns Hopkins\r University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Department\r of Neuroscience,Department of Ophthalmology, and\r Howard Hughes Medical Institute, The Johns Hopkins\r University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer P.","family":"Macke","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Department\r of Neuroscience,Department of Ophthalmology, and\r Howard Hughes Medical Institute, The Johns 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