{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:53:53Z","timestamp":1792738433641,"version":"4.5.0"},"reference-count":21,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,10,14]]},"abstract":"<jats:p>\n                    We have isolated a dominant mutation,\n                    <jats:italic>night blindness a (nba)<\/jats:italic>\n                    , that causes a slow retinal degeneration in zebrafish. Heterozygous\n                    <jats:italic>nba<\/jats:italic>\n                    fish have normal vision through 2\u20133 months of age but subsequently become night blind. By 9.5 months of age, visual sensitivity of affected fish may be decreased more than two log units, or 100-fold, as measured behaviorally. Electroretinographic (ERG) thresholds of mutant fish are also raised significantly, and the ERG b-wave shows a delayed implicit time. These defects are due primarily to a late-onset photoreceptor cell degeneration involving initially the rods but eventually the cones as well. Homozygous\n                    <jats:italic>nba<\/jats:italic>\n                    fish display an early-onset neuronal degeneration throughout the retina and elsewhere in the central nervous system. As a result, animals develop with small eyes and die by 4\u20135 days postfertilization (pf). These latter data indicate that the mutation affecting\n                    <jats:italic>nba<\/jats:italic>\n                    fish is not in a photoreceptor cell-specific gene.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.21.11645","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"11645-11650","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":126,"title":["A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific\u2009mutation"],"prefix":"10.1073","volume":"94","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Dowling","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1997,10,14]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"109","volume":"1","author":"Chader G J","year":"1991","unstructured":"G J Chader Prog Vet Comp Ophthalmol 1, 109\u2013126 (1991).","journal-title":"Prog Vet Comp Ophthalmol"},{"key":"e_1_3_3_2_2","volume-title":"Retinitis Pigmentosa","author":"Heckenlively J R","year":"1988","unstructured":"J R Heckenlively Retinitis Pigmentosa (Lippincott, Philadelphia, 1988)."},{"key":"e_1_3_3_3_2","first-page":"1659","volume":"34","author":"Berson E L","year":"1993","unstructured":"E L Berson Invest Ophthalmol Vis Sci 34, 1659\u20131676 (1993).","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(84)90636-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9370"},{"key":"e_1_3_3_6_2","first-page":"699","volume":"49","author":"Sheffield V C","year":"1991","unstructured":"V C Sheffield, G A Fishman, J S Beck, A E Kimura, E M Stone Am J Hum Genet 49, 699\u2013706 (1991).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8202715"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225078"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10545"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.37"},{"key":"e_1_3_3_12_2","volume-title":"The Zebrafish Book","author":"Westerfield M","year":"1995","unstructured":"M Westerfield The Zebrafish Book (Univ. of Oregon Press, Eugene, OR, 1995)."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960722)371:2<222::AID-CNE3>3.0.CO;2-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.229"},{"key":"e_1_3_3_15_2","volume-title":"The Retina: An Approachable Part of the Brain","author":"Dowling J E","year":"1987","unstructured":"J E Dowling The Retina: An Approachable Part of the Brain (Harvard Univ. 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