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Coimmunoprecipitations from lysates and culture media of cells transfected with expression vectors for EBI3 and\/or the p35 subunit of IL-12 now reveal a specific association of EBI3 with p35. Coexpression of EBI3 and p35 mutually facilitates their secretion. Most importantly, a large fraction of p35 in extracts of the trophoblast component of a human full-term normal placenta specifically coimmunoprecipitated with EBI3, indicating that EBI3 is in a heterodimer with p35,\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Because EBI3 is expressed in EBV-transformed B lymphocytes, tonsil, spleen, and placental trophoblasts, the EBI3\/p35 heterodimer is likely to be an important immunomodulator.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.22.12041","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:50Z","timestamp":1027679750000},"page":"12041-12046","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":272,"title":["Epstein\u2013Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric\u2009hematopoietin"],"prefix":"10.1073","volume":"94","author":[{"given":"Odile","family":"Devergne","sequence":"first","affiliation":[{"name":"Departments of Medicine and Microbiology and Molecular Genetics, Harvard Medical School and Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA 02115; and Department of Pathology and Cancer Research Center, The University of 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