{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:35Z","timestamp":1791644435609,"version":"4.3.4"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,10,28]]},"abstract":"<jats:p>Gamma frequency (about 20\u201370 Hz) oscillations occur during novel sensory stimulation, with tight synchrony over distances of at least 7 mm. Synchronization in the visual system has been proposed to reflect coactivation of different parts of the visual field by a single spatially extended object. We have shown that intracortical mechanisms, including spike doublet firing by interneurons, can account for tight long-range synchrony. Here we show that synchronous gamma oscillations in two sites also can cause long-lasting (&gt;1 hr) potentiation of recurrent excitatory synapses. Synchronous oscillations lasting &gt;400 ms in hippocampal area CA1 are associated with an increase in both excitatory postsynaptic potential (EPSP) amplitude and action potential afterhyperpolarization size. The resulting EPSPs stabilize and synchronize a prolonged beta frequency (about 10\u201325 Hz) oscillation. The changes in EPSP size are not expressed during non-oscillatory behavior but reappear during subsequent gamma-oscillatory events. We propose that oscillation-induced EPSPs serve as a substrate for memory, whose expression either enhances or blocks synchronization of spatially separated sites. This phenomenon thus provides a dynamical mechanism for storage and retrieval of stimulus-specific neuronal\u2009assemblies.<\/jats:p>","DOI":"10.1073\/pnas.94.22.12198","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"12198-12203","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":147,"title":["Recurrent excitatory postsynaptic potentials induced by synchronized fast cortical\u2009oscillations"],"prefix":"10.1073","volume":"94","author":[{"given":"Miles A.","family":"Whittington","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Imperial College School of Medicine at St. Mary\u2019s, London W2 1PG, United Kingdom; IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598; Department of Neurology, Columbia University, New York, NY 10032; and Department of Physiology, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"Traub","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Imperial College School of Medicine at St. Mary\u2019s, London W2 1PG, United Kingdom; IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598; Department of Neurology, Columbia University, New York, NY 10032; and Department of Physiology, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Imperial College School of Medicine at St. Mary\u2019s, London W2 1PG, United Kingdom; IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598; Department of Neurology, Columbia University, New York, NY 10032; and Department of Physiology, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Stanford","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Imperial College School of Medicine at St. Mary\u2019s, London W2 1PG, United Kingdom; IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598; Department of Neurology, Columbia University, New York, NY 10032; and Department of Physiology, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G. R.","family":"Jefferys","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Imperial College School of Medicine at St. Mary\u2019s, London W2 1PG, United Kingdom; IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598; Department of Neurology, Columbia University, New York, NY 10032; and Department of Physiology, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1997,10,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.18.030195.003011"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00202899"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91663-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/338334a0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5670"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.252.5009.1177"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11037"},{"key":"e_1_3_3_8_2","first-page":"62P","volume":"495","author":"Cobb S R","year":"1996","unstructured":"S R Cobb, K Halasy, I Vida, E H Buhl, P Somogyi J Physiol (London) 495, 62P, (abstr.). 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