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Sequence analysis of regions flanking the\n                    <jats:italic>Salmonella typhimurium sodC<\/jats:italic>\n                    gene encoding Cu,Zn-SOD demonstrates significant homology to \u03bb phage proteins, reflecting possible bacteriophage-mediated horizontal gene transfer of this determinant among pathogenic bacteria.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    deficient in Cu,Zn-SOD has reduced survival in macrophages and attenuated virulence in mice, which can be restored by abrogation of either the phagocyte respiratory burst or inducible nitric oxide synthase. Moreover, a\n                    <jats:italic>sodC<\/jats:italic>\n                    mutant is extremely susceptible to the combination of superoxide and nitric oxide. These observations suggest that SOD protects periplasmic or inner membrane targets by diverting superoxide and limiting peroxynitrite formation, and they demonstrate the ability of the respiratory burst and nitric oxide synthase to synergistically kill microbial pathogens\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.25.13997","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:32:33Z","timestamp":1027679553000},"page":"13997-14001","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":350,"title":["Periplasmic superoxide dismutase protects\n                    <i>Salmonella<\/i>\n                    from products of phagocyte NADPH-oxidase and nitric oxide\u2009synthase"],"prefix":"10.1073","volume":"94","author":[{"given":"Mary Ann","family":"De Groote","sequence":"first","affiliation":[{"name":"Departments of Medicine, Pathology, and Microbiology, University of Colorado Health Sciences Center, 4200 E. 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