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To explore the developmental potential of these cell-culture-derived precursors\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we have implanted them into the ventricles of embryonic rats. The transplanted cells formed intraventricular neuroepithelial structures and migrated in large numbers into the brain tissue. Embryonic-stem-cell-derived neurons, astrocytes, and oligodendrocytes incorporated into telencephalic, diencephalic, and mesencephalic regions and assumed phenotypes indistinguishable from neighboring host cells. These observations indicate that entirely\n                    <jats:italic>in vitro<\/jats:italic>\n                    -generated neural precursors are able to respond to environmental signals guiding cell migration and differentiation and have the potential to reconstitute neuronal and glial lineages in the central nervous system.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.26.14809","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:43:20Z","timestamp":1027680200000},"page":"14809-14814","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":251,"title":["<i>In vitro<\/i>\n                    -generated neural precursors participate in mammalian\u2009brain\u2009development"],"prefix":"10.1073","volume":"94","author":[{"given":"Oliver","family":"Br\u00fcstle","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-4092"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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