{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:13:35Z","timestamp":1793214815827,"version":"4.5.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,2,18]]},"abstract":"<jats:p>\n                    A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on the short arm of human chromosome 6. The predicted amino acid sequence of the MICA chain suggests that it folds similarly to typical class I chains and may have the capacity to bind peptides or other short ligands. Therefore, MICA is predicted to have a specialized function in antigen presentation or T cell recognition. During nucleotide sequence analyses of the MICA genomic clone, we found a triplet repeat microsatellite polymorphism of (GCT\/AGC)\n                    <jats:sub>n<\/jats:sub>\n                    in the transmembrane (TM) region of the MICA gene. In 68 HLA homozygous B cell lines, 5 distinct alleles of this microsatellite sequence were detected. One of them contained an additional one base insertion that created a frameshift mutation resulting in a premature termination codon in the TM region. This particular allele may encode a soluble, secreted form of the MICA molecule. In addition, we have investigated this microsatellite polymorphism in 77 Japanese patients with Beh\u00e7et disease, which is known to be associated with HLA-B51. The microsatellite allele consisting of 6 repetitions of GCT\/AGC was present at significantly higher frequency in the patient group (\n                    <jats:italic>Pc<\/jats:italic>\n                    = 0.00055) than in a control population. Furthermore, the (GCT\/AGC)\n                    <jats:sub>6<\/jats:sub>\n                    allele was present in all B51 positive patients and in an additional 13 B51 negative patients. These results suggest the possibility of a primary association of Beh\u00e7et disease with MICA rather than HLA-B.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.4.1298","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:39Z","timestamp":1027679499000},"page":"1298-1303","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":305,"title":["Triplet repeat polymorphism in the transmembrane region of the MICA gene: A strong association of six GCT repetitions with Beh\u00e7et\u2009disease"],"prefix":"10.1073","volume":"94","author":[{"given":"Nobuhisa","family":"Mizuki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Katsuyama","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiamak","family":"Bahram","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-11, Japan; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan; Japanese Red Cross, Kanagawa, Shonan Blood Center, 1837 Aiko, Atsugi, Kanagawa 243, Japan; Bioscience..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Inoko","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan; 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