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These two disorders are usually clinically and genetically distinct, but complementation analyses have assigned a few CS patients to the rare XP groups B, D, or G. The\n                    <jats:italic>XPG<\/jats:italic>\n                    gene encodes a structure-specific endonuclease that nicks damaged DNA 3\u2032 to the lesion during NER. Here we show that three XPG\/CS patients had mutations that would produce severely truncated XPG proteins. In contrast, two sibling XPG patients without CS are able to make full-length XPG, but with a missense mutation that inactivates its function in NER. These results suggest that XPG\/CS mutations abolish interactions required for a second important XPG function and that it is the loss of this second function that leads to the CS clinical phenotype.\n                  <\/jats:p>","DOI":"10.1073\/pnas.94.7.3116","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:43:20Z","timestamp":1027680200000},"page":"3116-3121","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":134,"title":["RETRACTED: A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second\u2009XPG\u2009function"],"prefix":"10.1073","volume":"94","author":[{"given":"Thierry","family":"Nouspikel","sequence":"first","affiliation":[{"name":"Department of Genetics and Microbiology, University Medical Centre (CMU), 9 Avenue de Champel, 1211 Geneva 4, Switzerland; Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7512; and Life Sciences Division, Building 934, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lalle","sequence":"additional","affiliation":[{"name":"Department of Genetics and Microbiology, University Medical Centre (CMU), 9 Avenue de Champel, 1211 Geneva 4, Switzerland; Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7512; and Life Sciences Division, Building 934, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Leadon","sequence":"additional","affiliation":[{"name":"Department of Genetics and Microbiology, University Medical Centre (CMU), 9 Avenue de Champel, 1211 Geneva 4, Switzerland; Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7512; and Life Sciences Division, Building 934, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla K.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Genetics and Microbiology, University Medical Centre (CMU), 9 Avenue de Champel, 1211 Geneva 4, Switzerland; Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7512; and Life Sciences Division, Building 934, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G.","family":"Clarkson","sequence":"additional","affiliation":[{"name":"Department of Genetics and Microbiology, University Medical Centre (CMU), 9 Avenue de Champel, 1211 Geneva 4, Switzerland; Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7512; and Life Sciences Division, Building 934, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1997,4]]},"reference":[{"key":"e_1_3_3_1_2","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg E C","year":"1995","unstructured":"E C Friedberg, G C Walker, W Siede DNA Repair and Mutagenesis (Am. 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