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Extensive lymphocytic infiltration of tissues, including lung, liver, gut, and bone, is observed, accompanied by tissue atrophy and inflammation. Although mature T cells are present, the absence of CD25 does affect the differentiation of thymocytes. While displaying normal development of CD2, CD3, CD4, and CD8 expression, CD25-deficient cortical thymocytes do not express CD1, and furthermore they fail to normally down-regulate levels of the anti-apoptotic protein bcl-2.<\/jats:p>","DOI":"10.1073\/pnas.94.7.3168","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:32:33Z","timestamp":1027679553000},"page":"3168-3171","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":368,"title":["Human immune disorder arising from mutation of the \u03b1 chain of the interleukin-2\u2009receptor"],"prefix":"10.1073","volume":"94","author":[{"given":"Nigel","family":"Sharfe","sequence":"first","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, University of Toronto and the Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjit K.","family":"Dadi","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, University of Toronto and the Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Shahar","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, University of Toronto and the Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim M.","family":"Roifman","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, University of Toronto and the Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1997,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.001333"},{"key":"e_1_3_3_2_2","unstructured":"Moller G. ed. 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