{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:28:43Z","timestamp":1791462523572,"version":"4.3.4"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"15","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,7,21]]},"abstract":"<jats:p>\n                    We report here the molecular cloning of an \u22481-Mb region of recurrent amplification at 20q13.2 in breast cancer and other tumors and the delineation of a 260-kb common region of amplification. Analysis of the 1-Mb region produced evidence for five genes,\n                    <jats:italic>ZNF217<\/jats:italic>\n                    ,\n                    <jats:italic>ZNF218<\/jats:italic>\n                    , and\n                    <jats:italic>NABC1<\/jats:italic>\n                    ,\n                    <jats:italic>PIC1L<\/jats:italic>\n                    (\n                    <jats:italic>PIC1-l<\/jats:italic>\n                    ike),\n                    <jats:italic>CYP24<\/jats:italic>\n                    , and a pseudogene\n                    <jats:italic>CRP<\/jats:italic>\n                    (\n                    <jats:italic>C<\/jats:italic>\n                    yclophillin\n                    <jats:italic>R<\/jats:italic>\n                    elated\n                    <jats:italic>P<\/jats:italic>\n                    seudogene).\n                    <jats:italic>ZNF217<\/jats:italic>\n                    and\n                    <jats:italic>NABC1<\/jats:italic>\n                    emerged as strong candidate oncogenes and were characterized in detail.\n                    <jats:italic>NABC1<\/jats:italic>\n                    is predicted to encode a 585-aa protein of unknown function and is overexpressed in most but not all breast cancer cell lines in which it was amplified.\n                    <jats:italic>ZNF217<\/jats:italic>\n                    is centrally located in the 260-kb common region of amplification, transcribed in multiple normal tissues, and overexpressed in all cell lines and tumors in which it is amplified and in two in which it is not.\n                    <jats:italic>ZNF217<\/jats:italic>\n                    is predicted to encode alternately spliced, Kruppel-like transcription factors of 1,062 and 1,108 aa, each having a DNA-binding domain (eight C2H2 zinc fingers) and a proline-rich transcription activation domain.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.15.8703","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:32:33Z","timestamp":1027679553000},"page":"8703-8708","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":244,"title":["Positional cloning of\n                    <i>ZNF<\/i>\n                    <i>217<\/i>\n                    and\n                    <i>NABC<\/i>\n                    <i>1<\/i>\n                    : Genes amplified at 20q13.2 and overexpressed in breast carcinoma"],"prefix":"10.1073","volume":"95","author":[{"given":"Colin","family":"Collins","sequence":"first","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. Box 2000, Fin-33521 Tampere, Finland; University of California San Francisco Cancer Center, San Francisco, CA 94143; Department of Medical Genetics, University of British Columbia, Vancouver, BC Canada V6T 2B5; Laboratory of Cancer Genetics, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Rommens","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. Box 2000, Fin-33521 Tampere, Finland; University of California San Francisco Cancer Center, San Francisco, CA 94143; Department of Medical Genetics, University of British Columbia, Vancouver, BC Canada V6T 2B5; Laboratory of Cancer Genetics, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kowbel","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. Box 2000, Fin-33521 Tampere, Finland; University of California San Francisco Cancer Center, San Francisco, CA 94143; Department of Medical Genetics, University of British Columbia, Vancouver, BC Canada V6T 2B5; Laboratory of Cancer Genetics, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. Box 2000, Fin-33521 Tampere, Finland; University of California San Francisco Cancer Center, San Francisco, CA 94143; Department of Medical Genetics, University of British Columbia, Vancouver, BC Canada V6T 2B5; Laboratory of Cancer Genetics, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Tanner","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. Box 2000, Fin-33521 Tampere, Finland; University of California San Francisco Cancer Center, San Francisco, CA 94143; Department of Medical Genetics, University of British Columbia, Vancouver, BC Canada V6T 2B5; Laboratory of Cancer Genetics, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-in","family":"Hwang","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. 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