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The predicted amino acid sequence of NaN can be aligned with the predicted structure of known Na channel \u03b1-subunits; all relevant landmark sequences, including positively charged S4 and pore-lining SS1\u2013SS2 segments, and the inactivation tripeptide IFM, are present at predicted positions. However, NaN exhibits only 42\u201353% similarity to other mammalian Na channels, including SNS\/PN3, indicating that it is a novel channel, and suggesting that it may represent a third subfamily of Na channels. NaN transcript levels are reduced significantly 7 days post axotomy in DRG neurons, consistent with previous findings of a reduction in TTX-R Na currents. The preferential expression of NaN in DRG and trigeminal ganglia and the reduction of NaN mRNA levels in DRG after axonal injury suggest that NaN, together with SNS\/PN3, may produce TTX-R currents in peripheral sensory neurons and may influence the generation of electrical activity in these cells.<\/jats:p>","DOI":"10.1073\/pnas.95.15.8963","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:52Z","timestamp":1027680052000},"page":"8963-8968","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":437,"title":["NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy"],"prefix":"10.1073","volume":"95","author":[{"given":"S. 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