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U.S.A."],"published-print":{"date-parts":[[1998,8,4]]},"abstract":"<jats:p>\n                    The protooncogene\n                    <jats:italic>MYC<\/jats:italic>\n                    plays an important role in the regulation of cellular proliferation, differentiation, and apoptosis and has been implicated in a variety of human tumors.\n                    <jats:italic>MYC<\/jats:italic>\n                    and the closely related\n                    <jats:italic>MYCN<\/jats:italic>\n                    encode highly conserved nuclear phosphoproteins (Myc and NMyc) that apparently function as transcription factors in the cell. We have identified a large and highly conserved nuclear protein that interacts directly with the transcriptional activating domain of Myc (designated \u201cprotein associated with Myc\u201d or Pam). Pam contains an extended amino acid sequence with similarities to a protein known as regulator of chromosome condensation (RCC1), which may play a role in the function of chromatin. The gene encoding Pam (\n                    <jats:italic>PAM<\/jats:italic>\n                    ) is expressed in all of the human tissue examined, but expression is exceptionally abundant in brain and thymus. Pam binds specifically to Myc, but not NMyc. The region in Myc required for binding to Pam includes a domain that is essential for the function of Myc and that is frequently mutated in Burkitt\u2019s lymphomas.\n                    <jats:italic>PAM<\/jats:italic>\n                    is located within a 300-kb region on chromosome 13q22.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.16.9172","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"9172-9177","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":125,"title":["Identification of a large Myc-binding protein that contains RCC1-like repeats"],"prefix":"10.1073","volume":"95","author":[{"given":"Qingbin","family":"Guo","sequence":"first","affiliation":[{"name":"G. W. Hooper Foundation and Cancer Research Institute, University of California, San Francisco, CA 94143; Section of Cellular and Molecular Oncogenesis, Division of Clinical Science, National Cancer Institute, Bethesda, MD 20892; and Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwu","family":"Xie","sequence":"additional","affiliation":[{"name":"G. W. Hooper Foundation and Cancer Research Institute, University of California, San Francisco, CA 94143; Section of Cellular and Molecular Oncogenesis, Division of Clinical Science, National Cancer Institute, Bethesda, MD 20892; and Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi V.","family":"Dang","sequence":"additional","affiliation":[{"name":"G. W. Hooper Foundation and Cancer Research Institute, University of California, San Francisco, CA 94143; Section of Cellular and Molecular Oncogenesis, Division of Clinical Science, National Cancer Institute, Bethesda, MD 20892; and Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison T.","family":"Liu","sequence":"additional","affiliation":[{"name":"G. W. Hooper Foundation and Cancer Research Institute, University of California, San Francisco, CA 94143; Section of Cellular and Molecular Oncogenesis, Division of Clinical Science, National Cancer Institute, Bethesda, MD 20892; and Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Bishop","sequence":"additional","affiliation":[{"name":"G. W. Hooper Foundation and Cancer Research Institute, University of California, San Francisco, CA 94143; Section of Cellular and Molecular Oncogenesis, Division of Clinical Science, National Cancer Institute, Bethesda, MD 20892; and Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1998,8,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1146\/annurev.bi.61.070192.004113","volume":"61","author":"Marcu K B","year":"1992","unstructured":"K B Marcu, S A Bossone, A J Patel Annu Rev Biochem 61, 809\u2013860 (1992).","journal-title":"Annu Rev Biochem"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-22681-0","volume-title":"c-Myc Function in Neoplasia","author":"Dang C V","year":"1995","unstructured":"C V Dang, L A Lee c-Myc Function in Neoplasia (Landes, 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