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However, evidence that\n                    <jats:italic>FHIT<\/jats:italic>\n                    is causally related to renal or other malignancies is controversial. We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma\/segment polarity gene,\n                    <jats:italic>patched<\/jats:italic>\n                    . This similarity involves two regions of\n                    <jats:italic>patched<\/jats:italic>\n                    , the putative sterol-sensing domain and the second extracellular loop that participates in the binding of sonic hedgehog. In the 3;8 translocation, TRC8 is fused to\n                    <jats:italic>FHIT<\/jats:italic>\n                    and is disrupted within the sterol-sensing domain. In contrast, the\n                    <jats:italic>FHIT<\/jats:italic>\n                    coding region is maintained and expressed. In a series of sporadic renal carcinomas, an acquired\n                    <jats:italic>TRC8<\/jats:italic>\n                    mutation was identified. By analogy to\n                    <jats:italic>patched<\/jats:italic>\n                    ,\n                    <jats:italic>TRC8<\/jats:italic>\n                    might function as a signaling receptor and other pathway members, to be defined, are mutation candidates in malignant diseases involving the kidney and thyroid.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.16.9572","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"9572-9577","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":127,"title":["The hereditary renal cell carcinoma 3;8 translocation fuses\n                    <i>FHIT<\/i>\n                    to a\n                    <i>patched-<\/i>\n                    related gene,\n                    <i>TRC8<\/i>"],"prefix":"10.1073","volume":"95","author":[{"given":"Robert M.","family":"Gemmill","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"West","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Boldog","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotake","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry A.","family":"Drabkin","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262; Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905; and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1998,8,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1056\/NEJM197909133011107","volume":"301","author":"Cohen A J","year":"1979","unstructured":"A J Cohen, F P Li, S Berg, D J Marchetto, S Tsai, S C Jacobs, R S Brown N Engl J Med 301, 592\u2013595 (1979).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.7326\/0003-4819-118-2-199301150-00005","volume":"118","author":"Li F P","year":"1993","unstructured":"F P Li, H J Decker, B Zbar, V P Stanton, G Kovacs, B R Seizinger, H Aburatani, A A Sandberg, S Berg, S Hosoe Ann Intern Med 118, 106\u2013111 (1993).","journal-title":"Ann Intern Med"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","volume":"260","author":"Latif F","year":"1993","unstructured":"F Latif, K Tory, J Gnarra, M Yao, F M Duh, M L Orcutt, T Stackhouse, I Kuzmin, W Modi, L Geil, et al. 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