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Unexpectedly, expression of human NF-H transgenes increased by up to 65%, the mean lifespan of SOD1\n                    <jats:sup>G37R<\/jats:sup>\n                    mice. Microscopic examination corroborated the protective effect of NF-H protein against SOD1 toxicity. Although massive neurodegeneration occurred in 1-yr-old mice expressing SOD1\n                    <jats:sup>G37R<\/jats:sup>\n                    alone, spinal root axons and motor neurons were remarkably spared in doubly SOD1\n                    <jats:sup>G37R<\/jats:sup>\n                    ;NF-H-transgenic littermates.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.16.9626","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"9626-9630","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":168,"title":["Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase"],"prefix":"10.1073","volume":"95","author":[{"given":"S\u00e9bastien","family":"Couillard-Despr\u00e9s","sequence":"first","affiliation":[{"name":"Centre for Research in Neuroscience, McGill University, Montreal General 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