{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:37Z","timestamp":1791081997487,"version":"4.1.0"},"reference-count":21,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,8,18]]},"abstract":"<jats:p>Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat gluten and related proteins. The large majority of patients expresses the HLA-DQ2 and\/or DQ8 molecules, and gluten-specific HLA-DQ-restricted T cells have been found at the site of the lesion in the gut. The nature of peptides that are recognized by such T cells, however, has been unclear so far. We now report the identification of a gliadin-derived epitope that dominantly is recognized by intestinal gluten-specific HLA-DQ8-restricted T cells. The characterization of such epitopes is a key step toward the development of strategies to interfere in mechanisms involved in the pathogenesis of celiac disease.<\/jats:p>","DOI":"10.1073\/pnas.95.17.10050","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:50Z","timestamp":1027679750000},"page":"10050-10054","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":188,"title":["Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin"],"prefix":"10.1073","volume":"95","author":[{"given":"Yvonne","family":"van de Wal","sequence":"first","affiliation":[{"name":"Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Gastroenterology, Free University Hospital, 108HV Amsterdam, The Netherlands; Department of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M. C.","family":"Kooy","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Gastroenterology, Free University Hospital, 108HV Amsterdam, The Netherlands; Department of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"van Veelen","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Gastroenterology, Free University Hospital, 108HV Amsterdam, The Netherlands; Department of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador A.","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Gastroenterology, Free University Hospital, 108HV Amsterdam, The Netherlands; Department of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa M.","family":"Mearin","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Gastroenterology, Free University Hospital, 108HV Amsterdam, The Netherlands; Department of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Molberg","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Gastroenterology, Free University Hospital, 108HV Amsterdam, The Netherlands; Department of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. 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